Osiceanu et al (in preparation) GRAMD1B
Bettegazzi et al (in preparation) eIF4B and BACE
Consonni et al (in preparation) Abeta and microglia
J Neuroinflamm?
2016
Bettegazzi B, Bertero A, Codazzi F, Grohovaz
F, Zacchetti D (submitted)
Activity-dependent phosphorylation of neuronal eIF4B provides a
link between synaptic signaling and protein translation
J Neurosci
2015
Codazzi F, Pelizzoni I, Zacchetti D, Grohovaz
F
Iron entry in neurons and astrocytes: a link with synaptic
activity (review)
Front Mol Neurosci. 2015 Jun 3;8:18.
doi: 10.3389/fnmol.2015.00018
2014
Maltecca F, Baseggio E, Consolato F, Mazza D, Podini P, Young SM
Jr, Drago I, Bahr BA, Puliti A, Codazzi F, Quattrini A,
Casari G.
Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28
model.
J Clin Invest. 2014 Dec 8. pii: 74770.
doi: 10.1172/JCI74770
Maccarinelli F, Pagani A, Cozzi A, Codazzi F, Di Giacomo
G, Capoccia S, Rapino S, Finazzi D, Politi LS, Cirulli F, Giorgio
M, Cremona O, Grohovaz F, Levi S
A novel neuroferritinopathy mouse model (FTL 498InsTC) shows
progressive brain iron dysregulation, morphological signs of early
neurodegeneration and motor coordination deficits.
Neurobiology of Disease Available online 4 November 2014
doi: 10.1016/j.nbd.2014.10.023
Lazzaro M, Bettegazzi B, Barbariga M, Codazzi F,
Zacchetti D, Alessio M (2014)
Ceruloplasmin
potentiates nitric oxide synthase activity and cytokines
secretion in activated microglia
Journal of Neuroinflammation, 11:164
doi: 10.1186/s12974-014-0164-9
Sardi C, Zambusi L, Finardi A, Ruffini F, Tolun AA, Dickerson IM,
Righi M, Zacchetti D, Grohovaz F, Provini L,
Furlan R, and Morara S. (2014)
Involvement of Calcitonin Gene-Related Peptide and Receptor
Component Protein in experimental autoimmune encephalomyelitis.
J Neuroimmunol. 2014 Jun 15;271(1-2):18-29.
doi: 10.1016/j.jneuroim.2014.03.008.
2013
Macco R, Pelizzoni
I, Consonni A, Vitali I,
Giacalone G, Martinelli Boneschi F, Codazzi F,
Grohovaz F^, and Zacchetti D^ (2013)
Astrocytes acquire resistance to iron-dependent oxidative stress
upon proinflammatory activation.
J. Neuroinflamm., 10:130
doi: 10.1186/1742-2094-10-130
Pelizzoni I, Zacchetti
D, Campanella A, Grohovaz
F^, and Codazzi F^ (2013)
Iron uptake in quiescent and inflammation-activated astrocytes: a
potentially neuroprotective control of iron burden.
Biochim Biophys Acta - Molecular Basis of Disease 1832:1326-33.
doi: 10.1016/j.bbadis.2013.04.007
2012
Pelizzoni I, Zacchetti D, Smith CP, Grohovaz F^, and Codazzi F^
(2012)
Expression of divalent metal transporter 1 in primary hippocampal
neurons: reconsidering its role in non-transferrin-bound iron
influx
J. Neurochem., 120: 269-278 [Epub
ahead of print]
doi: 10.1111/j.1471-4159.2011.07578.x
PubMed PMID:
22121954
2011
2008
2007
Chiulli N, Codazzi
F, Di Cesare A, Gravaghi C, Zacchetti
D*, Grohovaz F* (2007)
Sphingosylphosphocholine effects on cultured astrocytes reveal
mechanisms potentially involved in neurotoxicity in Niemann-Pick
type A disease
Eur. J. Neurosci. 26:875–881 (* corresponding authors)
doi:10.1111/j.1460-9568.2007.05732.x
Mihailovich M, Thermann R, Grohovaz F, Hentze MW, Zacchetti D (2007)
Complex
translational
regulation
of
BACE1
involves
upstream
uAUGs
and
stimulatory
elements
within
the
5'
untranslated
region
Nucl. Acids Res. 35:2975-2985.
full
text
Zacchetti D, Chieregatti E, Bettegazzi B,
Mihailovich M, Sousa VL, Grohovaz
F, Meldolesi J (2007)
BACE1 expression and activity: relevance in Alzheimer’s disease
Neurodegenerative Dis. 4:117-126 (review)
2006
Di Cesare A, Del Piccolo P, Zacchetti D*, and Grohovaz F* (2006)2005
Negri L, Lattanzi R, Giannini E, Colucci MA, Mignogna G, Barra D, Grohovaz F, Codazzi F, Kaiser A, Kreil G, Melchiorri P. (2005)2004
De Pietri Tonelli D.*, Mihailovich M.*, Di Cesare A., Codazzi F., Grohovaz F. and Zacchetti D. (2004)2003
De Pietri Tonelli D., Mihailovich M., Schnurbus
R., Pesole G., Grohovaz F., and Zacchetti D.
(2003)
Translational
control of Scamper expression via a cell-specific internal
ribosome entry site.
Nucl. Acids Res. 31: 2508-2513
full
text
2002
Ehehalt R., Michel B., De Pietri Tonelli D., Zacchetti
D., Simons K., and Keller P. (2002)
Splice
variants of the beta-site APP-cleaving enzyme BACE1 in human
brain and pancreas
Biochem. Biophys. Res. Comm. 293: 30-37
Schnurbus R., De Pietri Tonelli D., Grohovaz
F., and Zacchetti D. (2002)
Re-evaluation
of
primary
structure,
topology,
and
localization
of
Scamper,
a
putative
intracellular
Ca2+
channel
activated
by spingosylphosphocholine.
Biochem. J. 362: 183-189
Bertuzzi F., Grohovaz F., Maffi P., Caumo A.,
Aldrighetti L., Nano R., Hengster P., Calori G., Di Carlo V.,
Bonifacio E., and Secchi A. (2002)
Succesful
transplantation of human islets in recipients bearing a kidney
graft.
Diabetologia 45: 77-84
2001
Pezzati R., Meldolesi J., and Grohovaz F. (2001)
Ultra
rapid calcium events in electrically stimulated frog nerve
terminals.
Biochem. Biophys. Res. Comm. 2001; 285:724-727
Meldolesi J. and Grohovaz F. (2001)
Total
calcium ultrastructure: advances in excitable cells.
Cell Calcium 2001; 30: 1-8 (review)
Codazzi F., Teruel M.N., and Meyer T. (2001)
Control
of
astrocyte
Ca2+
oscillations
and
waves
by
oscillating
translocation
and
activation
of
protein
kinase
C.
Curr. Biol. 2001; 11: 1089-1097
2000
Haugh J.M., Codazzi F., Teruel M., and Meyer T. (2000)
Spatial
sensing in fibroblasts mediated by 3' phosphoinositide.
J. Cell Biol. 151: 1269-1279
Lorenzon P., Grohovaz F., and Ruzzier F. (2000)
Voltage-
and ligand-gated ryanodine receptors are functionally separated
in developing C2C12 mouse myotubes.
J. Physiol. 525.2: 499-507
Benting J., Lecat S., Zacchetti D., and Simons K. (2000)
Protein
expression in Drosophila Schneider cells.
Analytical Biochemistry 278: 59-68
1999
Bertuzzi F., Davalli A.M., Nano R., Socci C., Codazzi
F., Fesce R., Di Carlo V., Pozza G., and Grohovaz F.
(1999)
Mechanisms
of Coordination of Ca2+ Signals in Pancreatic Islet Cells.
Diabetes 48: 1971-1978
Tonini R., Grohovaz F., Laporta C.A.M., and Mazzanti M.
(1999)
Gating
mechanism
of
the
nuclear
pore
complex
channel
in
isolated
neonatal
and
adult
mouse
liver
nuclei.
Faseb J. 13: 1395-1403
Cheong K.H., Zacchetti D., Schneeberger E.E., and
Simons K. (1999)
VIP17/MAL,
a lipid raft-associated protein, is involved in apical transport
in MDCK cells.
Proc. Natl. Acad. Sci. USA. 96: 6241-8
Improta Brears T., Whorton A.R., Codazzi F., York J.D.,
Meyer T., McDonnell D.P. (1999)
Estrogen-induced
activation of mitogen-activated protein kinase requires
mobilization of intracellular calcium.
Proc. Natl. Acad. Sci. USA. 96: 4686-91
Kasai H., Kishimoto T., Liu T.T., Miyashita Y., Podini P., Grohovaz
F., and Meldolesi J. (1999)
Multiple
and diverse forms of regulated exocytosis in wild-type and
defective PC12 cells.
Proc. Natl. Acad. Sci. USA. 96: 945-9
Pezzati R. and Grohovaz F. (1999)
The
frog neuromuscular junction revisited after
quick-freezing-freeze-drying: ultrastructure, immunogold
labelling and high resolution calcium mapping.
Philos. Trans. R. Soc. Lond. B. Biol. Sci. 354: 373-8
1998
Martino G., Grohovaz F.,
Brambilla E., Codazzi F., Consiglio A., Clementi E.,
Filippi M., Comi G., and Grimaldi L.M. (1998)
Proinflammatory
cytokines regulate antigen-independent T-cell activation by two
separate calcium-signaling pathways in multiple sclerosis
patients.
Ann. Neurol. 43: 340-9
1997
Pezzati R., Bossi M., Podini P., Meldolesi J., and Grohovaz F. (1997)
High-resolution
calcium
mapping
of
the
endoplasmic
reticulum-Golgi-exocytic
membrane
system.
Electron
energy
loss
imaging
analysis
of
quick frozen-freeze dried PC12 cells.
Mol. Biol. Cell. 8: 1501-12
1996
Grohovaz F., Bossi M., Pezzati R., Meldolesi J.,
and Torri-Tarelli F. (1996)
High
resolution
ultrastructural
mapping
of
total
calcium:
electron
spectroscopic
imaging/electron
energy
loss
spectroscopy
analysis
of
a physically/chemically processed nerve-muscle preparation.
Proc. Natl. Acad. Sci. U.S.A. 93: 4799-803
Codazzi F., Racchetti G., Grohovaz F., and
Meldolesi J. (1996)
Transduction
signals induced in rat brain cortex astrocytes by the HIV-1
gp120 glycoprotein.
FEBS Lett. 384: 135-7
Bertuzzi F., Zacchetti D., Berra C., Socci C., Pozza
G., Pontiroli A.E., and Grohovaz F. (1996)
Intercellular
Ca2+ waves sustain coordinate insulin secretion in pig islets of
Langerhans.
FEBS Lett. 379: 21-5
1995
D'Andrea P. and Grohovaz F. (1995)
[Ca2+]i
oscillations in rat chromaffin cells: frequency and amplitude
modulation by Ca2+ and InsP3.
Cell Calcium 17: 367-74
Codazzi F., Menegon A., Zacchetti D., Ciardo A., Grohovaz
F., and Meldolesi J. (1995)
HIV-1
gp120
glycoprotein
induces
[Ca2+]i
responses
not
only
in
type-2
but
also
type-1
astrocytes
and
oligodendrocytes of the rat cerebellum.
Eur. J. Neurosci. 7: 1333-41
Lorenzon P.*, Zacchetti D.*, Codazzi F.,
Fumagalli G., Meldolesi J., and Grohovaz F. (1995)
Ca2+
waves in PC12 neurites: a bidirectional, receptor-oriented form
of Ca2+ signaling.
J. Cell Biol. 129: 797-804 (* shared contribution)
Zacchetti D., Peranen J., Murata M., Fiedler K., and
Simons K. (1995)
VIP17/MAL,
a proteolipid in apical transport vesicles.
FEBS-Lett. 377: 465-9
Bastianutto C., Clementi E., Codazzi F., Podini P., De
Giorgi F., Rizzuto R., Meldolesi J., and Pozzan T. (1995)
Overexpression
of
calreticulin
increases
the
Ca2+
capacity
of
rapidly
exchanging
Ca2+
stores
and
reveals
aspects
of their lumenal microenvironment and function.
J. Cell Biol. 130: 847-55
Ceccaldi P.E., Grohovaz F., Benfenati F., Chieregatti
E., Greengard P., and Valtorta F. (1995)
Dephosphorylated
synapsin I anchors synaptic vesicles to actin cytoskeleton: an
analysis by videomicroscopy.
J. Cell Biol. 128: 905-12
1994
D'Andrea P., Codazzi F., Zacchetti D., Meldolesi J., and Grohovaz
F. (1994)
Oscillations
of cytosolic calcium in rat chromaffin cells: dual modulation in
frequency and amplitude.
Biochem. Biophys. Res. Commun. 205: 1264-9
Fesce R., Grohovaz F., Valtorta F., and Meldolesi J.
(1994)
Neurotransmitter
release: fusion or 'kiss-and-run'?
Trends in Cell Biology, 4:1-4 (review)
1993
Grohovaz F., Lorenzon P., Ruzzier F., and Zorec R. (1993)
Properties
of acetylcholine receptors in adult rat skeletal muscle fibers
in culture.
J-Membr-Biol. 136: 31-42
D'Andrea P., Zacchetti D., Meldolesi J., and Grohovaz F. (1993)
Mechanism
of [Ca2+]i oscillations in rat chromaffin cells. Complex
Ca(2+)-dependent regulation of a ryanodine-insensitive
oscillator.
J. Biol. Chem. 268: 15213-20
Valtorta F., Ceccaldi P.E., Grohovaz F., Chieregatti E.,
Fesce R., and Benfenati F. (1993)
Fluorescence
approaches to the study of the actin-nucleating and bundling
activities of synapsin I.
J. Physiol. Paris 87: 117-22 (review)
Grohovaz F., Zacchetti D., Lorenzon P.,
Meldolesi J., and D'Andrea P. (1993)
Receptor-mediated
intracellular signalling: oscillations and waves of cytosolic
calcium.
Biochem. Soc. Trans. 21: 1129-32 (review)
1992
Torri Tarelli F., Bossi M., Fesce R., Greengard P., and
Valtorta F. (1992)
Synapsin-I
partially dissociates from synaptic vesicles during exocytosis
induced by electrical stimulation.
Neuron 9:1143-1153
Clementi E., Racchetti G., Zacchetti D., Panzeri M.C.,
and Meldolesi J. (1992)
Differential
expression of markers and activities in a group of PC12 nerve
cell clones.
Europ. J. Neurosci., 4: 944-953
Clementi E., Scheer H., Zacchetti D., Fasolato C.,
Pozzan T., and Meldolesi J. (1992)
Receptor-activated
Ca2+ influx. Two independently regulated mechanisms of influx
stimulation coexist in neurosecretory PC12 cells.
J. Biol. Chem. 267: 2164-72
Meldolesi J., Villa A., Podini P., Clementi E., Zacchetti D.,
D'Andrea P., Lorenzon P., and Grohovaz F.
(1992)
Intracellular
Ca2+ stores in neurons. Identification and functional aspects.
J. Physiol. Paris 86: 23-30 (review)
1991
Torri Tarelli F., Passafaro M., Clementi F., and Sher E.
(1991)
Presynaptic
localization of -conotoxin-sensitive calcium
channels at the frog neuromuscular junction.
Brain Res. 547:331-334
Zacchetti D., Clementi E., Fasolato C., Lorenzon P.,
Zottini
M., Grohovaz F., Fumagalli G., Pozzan T., and Meldolesi J.
(1991)
Intracellular
Ca2+
pools
in
PC12
cells.
A
unique,
rapidly
exchanging
pool
is
sensitive
to
both
inositol 1,4,5-trisphosphate and caffeine-ryanodine.
J. Biol. Chem. 266: 20152-8
Fasolato C., Zottini M., Clementi E., Zacchetti D.,
Meldolesi J., and Pozzan T. (1991)
Intracellular
Ca2+
pools
in
PC12
cells.
Three
intracellular
pools
are
distinguished
by
their
turnover
and
mechanisms of Ca2+ accumulation, storage, and release.
J. Biol. Chem. 266: 20159-67
Grohovaz F., Zacchetti D., Clementi E., Lorenzon
P., Meldolesi J., and Fumagalli G. (1991)
[Ca2+]i
imaging
in
PC12
cells:
multiple
response
patterns
to
receptor
activation
reveal
new
aspects
of
transmembrane signaling.
J. Cell Biol. 113: 1341-50
Meldolesi J., Clementi E., Fasolato C., Zacchetti D.,
and Pozzan T. (1991)
Ca2+
influx following receptor activation.
Trends Pharmacol. Sci. 12: 289-92 (review)
Grohovaz-F; Zacchetti-D; D'-Andrea-P; Lorenzon-P;
Meldolesi-J (1992)
[Ca2+]i
effects of bradykinin B2 receptor activation in PC12 cells.
Agents-Actions-Suppl. 38(Pt 2): 9-15
Clementi E, Scheer H, Zacchetti D, Racchetti G,
Meldolesi J (1992)
PC12
cell clones: experimental tools for studying transmembrane
signalling and Ca2+ stores.
Pharmacol. Res. 25 Suppl 1:95-6
Zacchetti-D; Lorenzon-P; Scheer-H; Clementi-E;
Meldolesi-J; Fumagalli-G; Grohovaz-F (1992)
Receptor
activation and Ca2+ homeostasis studied by videoimaging.
Pharmacol-Res. 1992 Feb-Mar; 25 Suppl 1: 93-4
Fumagalli-G; Zacchetti-D; Lorenzon-P; Grohovaz-F
(1991)
Fluorimetric
approaches to the study of calcium transients in living cells.
Cytotechnology. 1991; 5 Suppl 1: 99-102
Meldolesi J, Gatti G, Grohovaz F.
Role of Ca2+ in the regulation of energy metabolism in neurons and
nerve cells.
In Neuroenergetics: relevance for functional brain imaging.
Frackowiak R.S.J, Magistretti P.J., Shulman R.G., Altman J.S.,
Adams M. eds. HFSP Workshop XI, 107-117 (2001)
Fumagalli G, Zacchetti D, Verderio C, Codazzi
F, Grohovaz F
Variazioni spaziali e temporali della concentrazione citosolica
dello ione calcio in cellule viventi.
In "Marcello Malpighi Scienziato Universale" da "Studi e memorie
per la storia dell'Universita' di Bologna" nuova serie vol IX, a
cura di Bernabeo e Pallotti, 1995
R. Fesce and D. Zacchetti.
Calcium fluxes and distribution in neurons.
In "Bioelectrochemistry IV". Nerve-muscle function", G. Milazzo
Ed, 1994.
J. Meldolesi, A. Villa, P. D'Andrea, P. Lorenzon,
E. Clementi and F. Grohovaz.
[Ca2+]i control in rat chromaffin cells and PC12 cells.
J. Endocrinol. Invest. 16(s),15, 1993.
J. Meldolesi, A. Ciardo, A. Villa and F. Grohovaz.
Intracellular Ca2+ stores: why, where and how.
In: New Developments in Lipid-Protein Interactions and Receptor
Function. K. W. A. Wirtz ed., Plenum Press, New York-London, 1993.
Zacchetti-D; Lorenzon-P; Fumagalli-G; Grohovaz
F
Analisi spettrofluorimetrica quantitativa di transienti ionici in
cellule in coltura.
Microscopia Elettronica 1991; 12: 51-57
F. Ruzzier, F. Grohovaz, P. Lorenzon and R. Zorec.
Properties of acetylcholine receptors in isolated skeletal muscle
fibres in culture.
In: Restorative Neurology, (Wernig ed.) 5:145-150, Elsevier
North-Holland, 1991.
Submissions to public sequence databases
Accession number AF338816
Michel B, De Pietri Tonelli D, Zacchetti D and
Keller P (2001)
Homo sapiens beta-site APP cleaving enzyme type B mRNA, complete
cds (BACE-1B)
Accession number AF338817
Zacchetti D, De Pietri Tonelli D and Schnurbus
R (2001)
Homo sapiens beta-site APP cleaving enzyme type C mRNA, complete
cds (BACE-1C)
Accession number AF324837
Zacchetti D, Schnurbus R, De Pietri Tonelli
D (2000)
Homo sapiens beta-site APP cleaving enzyme mRNA, partial cds,
alternatively spliced
Accession number AF263546
Zacchetti D, Schnurbus R, De Pietri Tonelli
D (2000)
Scamper (Canis familiaris)
Accession number X92505
Zacchetti D (1995)
VIP17/MAL (Canis familiaris)